Structure of PDB 3n75 Chain A

Receptor sequence
>3n75A (length=711) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MNVIAILNHMGVYFKEEPIRELHRALERLNFQIVYPNDRDDLLKLIENNA
RLCGVIFDWDKYNLELCEEISKMNENLPLYAFANTYSTLDVSLNDLRLQI
SFFEYALGAAEDIANKIKQTTDEYINTILPPLTKALFKYVREGKYTFCTP
GHMGGTAFQKSPVGSLFYDFFGPNTMKSDISISVSELGSLLDHSGPHKEA
EQYIARVFNADRSYMVTNGTSTANKIVGMYSAPAGSTILIDRNCHKSLTH
LMMMSDVTPIYFRPTRNAYGILGGIPQSEFQHATIAKRVKETPNATWPVH
AVITNSTYDGLLYNTDFIKKTLDVKSIHFDSAWVPYTNFSPIYEGKCGMS
GGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDVNEETFNEAYMMHTTTS
PHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLRTESDGWF
FDVWQPDHIDTTECWPLRSDSTWHGFKNIDNEHMYLDPIKVTLLTPGMEK
DGTMSDFGIPASIVAKYLDEHGIVVEKTGPYNLLFLFSIGIDKTKALSLL
RALTDFKRAFDLNLRVKNMLPSLYREDPEFYENMRIQELAQNIHKLIVHH
NLPDLMYRAFEVLPTMVMTPYAAFQKELHGMTEEVYLDEMVGRINANMIL
PYPPGVPLVMPGEMITEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQA
DGRYTVKVLKE
3D structure
PDB3n75 Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H245 D330 K367
Catalytic site (residue number reindexed from 1) H245 D330 K367
Enzyme Commision number 4.1.1.18: lysine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G4P A R97 R206 K417 G418 R97 R206 K417 G418 MOAD: Kd=12.8nM
PDBbind-CN: -logKd/Ki=7.89,Kd=12.8nM
BS02 G4P A R558 L564 R565 N568 R585 R558 L564 R565 N568 R585 MOAD: Kd=12.8nM
PDBbind-CN: -logKd/Ki=7.89,Kd=12.8nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008923 lysine decarboxylase activity
GO:0016831 carboxy-lyase activity
GO:0042802 identical protein binding
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0006554 lysine catabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3n75, PDBe:3n75, PDBj:3n75
PDBsum3n75
PubMed21278708
UniProtP0A9H3|LDCI_ECOLI Inducible lysine decarboxylase (Gene Name=cadA)

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