Structure of PDB 3n71 Chain A

Receptor sequence
>3n71A (length=468) Species: 10090 (Mus musculus) [Search protein sequence]
MTIGSMENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFDSLINF
VCHTCFKRQEKLHRCGQCKFAHYCDRTCQKDAWLNHKNECAAIKKYGKVP
NENIRLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHFGEEEQKELRVD
VDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPN
LGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALGKISEGEELTV
SYIDFLHLSEERRRQLKKQYYFDCSCEHCQKGLKDDLFLAAKEDPKPSQE
VVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNLYV
LRLLSIASEVLSYLQAYEEASHYARRMVDGYMKLYHHNNAQLGMAVMRAG
LTNWHAGHIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRMQTEMELRM
FRQNEFMYHKMREAALNN
3D structure
PDB3n71 Crystal Structure of Cardiac-specific Histone Methyltransferase SmyD1 Reveals Unusual Active Site Architecture.
ChainA
Resolution2.3 Å
3D
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Enzymatic activity
Enzyme Commision number 2.1.1.354: [histone H3]-lysine(4) N-trimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG A K17 R19 Q133 H135 G202 L203 N205 H206 Y252 Y270 F272 K17 R19 Q133 H135 G202 L203 N205 H206 Y252 Y270 F272
BS02 ZN A C52 C55 C78 C52 C55 C78
BS03 ZN A C65 C68 H86 C90 C65 C68 H86 C90
BS04 ZN A C208 C274 C279 C208 C274 C279
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0042800 histone H3K4 methyltransferase activity
GO:0046872 metal ion binding
GO:0140999 histone H3K4 trimethyltransferase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0007507 heart development
GO:0010831 positive regulation of myotube differentiation
GO:0032259 methylation
GO:0035914 skeletal muscle cell differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3n71, PDBe:3n71, PDBj:3n71
PDBsum3n71
PubMed20943667
UniProtP97443|SMYD1_MOUSE Histone-lysine N-methyltransferase Smyd1 (Gene Name=Smyd1)

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