Structure of PDB 3n0t Chain A

Receptor sequence
>3n0tA (length=452) Species: 9606 (Homo sapiens) [Search protein sequence]
DPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGN
EGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTE
LLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPH
LVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQI
KDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYP
TDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYR
LYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDEL
RQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRR
NLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAAR
RE
3D structure
PDB3n0t Human dipeptidyl peptidase DPP7
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.14.2: dipeptidyl-peptidase II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OPY A E78 S162 P188 M271 D334 T336 G337 W347 W420 E51 S135 P161 M244 D307 T309 G310 W320 W393 BindingDB: IC50=130nM
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0070008 serine-type exopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:1905146 lysosomal protein catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005764 lysosome
GO:0005794 Golgi apparatus
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0035578 azurophil granule lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3n0t, PDBe:3n0t, PDBj:3n0t
PDBsum3n0t
PubMed
UniProtQ9UHL4|DPP2_HUMAN Dipeptidyl peptidase 2 (Gene Name=DPP7)

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