Structure of PDB 3my1 Chain A

Receptor sequence
>3my1A (length=315) Species: 9606 (Homo sapiens) [Search protein sequence]
DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE
KEGFPITALREIKILQLLKHENVVNLIEICRTKKGSIYLVFDFCEHDLAG
LLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV
LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDL
WGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELY
EKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH
DFFWSDPMPSDLKGM
3D structure
PDB3my1 Halogen bonds form the basis for selective P-TEFb inhibition by DRB
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D149 K151 A153 N154 D167 S180 T191
Catalytic site (residue number reindexed from 1) D137 K139 A141 N142 D155 S168 T179
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RFZ A A46 D104 F105 C106 L156 D167 A41 D92 F93 C94 L144 D155 PDBbind-CN: -logKd/Ki=5.45,IC50=3.58uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3my1, PDBe:3my1, PDBj:3my1
PDBsum3my1
PubMed20851342
UniProtP50750|CDK9_HUMAN Cyclin-dependent kinase 9 (Gene Name=CDK9)

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