Structure of PDB 3mxi Chain A

Receptor sequence
>3mxiA (length=219) Species: 10090 (Mus musculus) [Search protein sequence]
TLPHGHMQTLIFLNLEATGLPSSRPEVTELCLLAVHRRALESQGHPPPVP
RPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILL
RAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAA
LKALEQASKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALL
QWVDEHARPFSTVKPMYGT
3D structure
PDB3mxi X-ray Crystal Structures of TREX1 3' Exonuclease Autoimmune Disease Mutants
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E20 A21 L24 G80 I84 T85 H124 N125 R128 Y129 S176 S178 L179 H195 E16 A17 L20 G72 I76 T77 H116 N117 R120 Y121 S160 S162 L163 H179
BS02 CA A N18 E20 H195 D200 N14 E16 H179 D184
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:3mxi, PDBe:3mxi, PDBj:3mxi
PDBsum3mxi
PubMed
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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