Structure of PDB 3mxf Chain A

Receptor sequence
>3mxfA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB3mxf Selective inhibition of BET bromodomains.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JQ1 A W81 P82 L92 L94 N140 I146 M149 W40 P41 L51 L53 N99 I105 M108 PDBbind-CN: -logKd/Ki=7.31,Kd=49nM
External links
PDB RCSB:3mxf, PDBe:3mxf, PDBj:3mxf
PDBsum3mxf
PubMed20871596
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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