Structure of PDB 3mwa Chain A

Receptor sequence
>3mwaA (length=330) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
GLVPRGSMGFKVKLEKRRNAINTCLCIGLDPDEKDIENFMKNEKENNYNN
IKKNLKEKYINNVSIKKDILLKAPDNIIREEKSEEFFYFFNHFCFYIINE
TNKYALTFKMNFAFYIPYGSVGIDVLKNVFDYLYELNIPTILDMKINDIG
NTVKNYRKFIFEYLKSDSCTVNIYMGTNMLKDICYDEEKNKYYSAFVLVK
TTNPDSAIFQKNLSLDNKQAYVIMAQEALNMSSYLNLEQNNEFIGFVVGA
NSYDEMNYIRTYFPNCYILSPGIGAQNGDLHKTLTNGYHKSYEKILINIG
RAITKNPYPQKAAQMYYDQINAILKQNMES
3D structure
PDB3mwa Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase covalently modified by 2-prime-fluoro-6-iodo-UMP
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UFT A D23 K102 N104 K138 T194 T195 P264 Q269 G293 R294 D30 K109 N111 K145 T201 T202 P271 Q276 G300 R301
BS02 UFT A D141 I142 T145 D148 I149 T152
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3mwa, PDBe:3mwa, PDBj:3mwa
PDBsum3mwa
PubMed
UniProtQ8IJH3

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