Structure of PDB 3muo Chain A

Receptor sequence
>3muoA (length=684) Species: 648 (Aeromonas caviae) [Search protein sequence]
LHYPVTRQGEQVDHYFGQAVADPYRWLEDDRSPETEAWVKAQNAVTQDYL
AQIPYRAAIKEKLAASWNYAKEGAPFWWGRYHYFFKNDGLQNQNVLWRQQ
EGKPAEVFLDPNTLSPDGTTALDQLSFSRDGRILAYSLSLAGSDWREIHL
MDVESKQPLETPLKDVKFSGISWLGNEGFFYSSYDKPDGSELSARTDQHK
VYFHRLGTAQEDDRLVFGAIPAQHHRYVGATVTEDQRFLLISAANSTSGN
RLYVKDLSQENAPLLTVQGDLDADVSLVDNKGSTLYLLTNRDAPNRRLVT
VDAANPGPAHWRDLIPERQQVLTVHSGSGYLFAEYMVDATARVEQFDYEG
KRVREVALPGLGSVSGFNGYWWDPALYFGFENYAQPPTLYRFEPKSGAIS
LYRASAAPFKPEDYVSEQRFYQSKDGTRVPLIISYRKGLKLDGSNPTILY
GYGGFDVSLTPSFSVSVANWLDLGGVYAVANLRGGGEYGQAWHLAGTQQN
KQNVFDDFIAAAEYLKAEGYTRTDRLAIRGGSNGGLLVGAVMTQRPDLMR
VALPAVGVLDMLRYHTFTAGTGWAYDYGTSADSEAMFDYLKGYSPLHNVR
PGVSYPSTMVTTADHDDRVVPAHSFKFAATLQADNAGPHPQLIRIETNAG
HGAGTPVAKLIEQSADIYAFTLYEMGYRELPRQP
3D structure
PDB3muo Route of Substrate Entry in Prolyl Endopeptidase
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y458 S538 D622 H657
Catalytic site (residue number reindexed from 1) Y452 S532 D616 H651
Enzyme Commision number 3.4.21.26: prolyl oligopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZPR A T253 Y458 F461 S538 N539 W579 R624 V625 T247 Y452 F455 S532 N533 W573 R618 V619
BS02 ZPR A Y456 Y483 R535 G537 V562 H657 S670 Y674 Y450 Y477 R529 G531 V556 H651 S664 Y668
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
GO:0070012 oligopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3muo, PDBe:3muo, PDBj:3muo
PDBsum3muo
PubMed
UniProtQ9X6R4

[Back to BioLiP]