Structure of PDB 3muf Chain A

Receptor sequence
>3mufA (length=160) Species: 210 (Helicobacter pylori) [Search protein sequence]
QHLVLIGFMGSGKSSLAQELGLALKLEVLDTDMIISERVGLSVREIFEEL
GEDNFRMFEKNLIDELKTLKTPHVISTGGGIVMHENLKGLGTTFYLKMDF
ETLIKRLNQKEREKRPLLNNLTQAKELFEKRQALYEKNASFIIDARGGLN
NSLKQVLQFI
3D structure
PDB3muf Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.71: shikimate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G11 S12 G13 K14 S15 S16 M99 R107 G148 G149 G10 S11 G12 K13 S14 S15 M98 R106 G147 G148
BS02 S3P A M10 D33 R57 G79 G80 G81 R116 R132 M9 D32 R56 G78 G79 G80 R115 R131 PDBbind-CN: -logKd/Ki=6.49,Kd=0.32uM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004765 shikimate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0016310 phosphorylation
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3muf, PDBe:3muf, PDBj:3muf
PDBsum3muf
PubMed22438938
UniProtP56073|AROK_HELPY Shikimate kinase (Gene Name=aroK)

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