Structure of PDB 3mtc Chain A

Receptor sequence
>3mtcA (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
MYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLS
KEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEH
AAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEE
YERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDV
EKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTG
SDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFD
IGVRVVAHHH
3D structure
PDB3mtc Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.36: phosphoinositide 5-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N275 E303 N18 E46
BS02 PIF A E303 L306 K308 I373 N379 K380 H404 Y502 K516 R518 E46 L49 K51 I116 N122 K123 H147 Y245 K259 R261
Gene Ontology
Molecular Function
GO:0016791 phosphatase activity
GO:0052745 inositol phosphate phosphatase activity
Biological Process
GO:0046856 phosphatidylinositol dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3mtc, PDBe:3mtc, PDBj:3mtc
PDBsum3mtc
PubMed24704254
UniProtP32019|I5P2_HUMAN Type II inositol 1,4,5-trisphosphate 5-phosphatase (Gene Name=INPP5B)

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