Structure of PDB 3mr3 Chain A

Receptor sequence

>3mr3A (length=428) Species: 9606 (Homo sapiens)

GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQPISADLLPSTYIEG
LPQGETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAI
ERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRK
IRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRG
IEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTK
DRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIK
NCNTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 3mr3 Structure and mechanism of human DNA polymerase eta.
• Chain: A
• Resolution: 1.75 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 K86 R93 K293 K311 P316 K317 T318 G320 S322 K323 N324 P326 G327	Q41 Y42 W45 K89 R96 K289 K307 P312 K313 T314 G316 S318 K319 N320 P322 G323
BS02	dna	A	S113 E116 K224 S257 G259 K261 L262 T364 Q365 R377 L381 R382 R383 C384	S116 E119 K220 S253 G255 K257 L258 T360 Q361 R373 L377 R378 R379 C380
BS03	DZ4	A	D13 M14 D15 C16 F17 F18 Y52 R55 R61 D115 K231	D16 M17 D18 C19 F20 F21 Y55 R58 R64 D118 K227
BS04	MG	A	D13 M14 D115	D16 M17 D118
BS05	MG	A	D13 D115 E116	D16 D118 E119
BS06	DZ4	A	S257 K293 N294 W297	S253 K289 N290 W293

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:3mr3, PDBe:3mr3, PDBj:3mr3
• PDBsum: 3mr3
• PubMed: 20577208
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)