Structure of PDB 3mqd Chain A

Receptor sequence

>3mqdA (length=407) Species: 359391 (Brucella abortus 2308)

MRRVVVTGMGIVSSIGSNTEEVTASLREAKSGISRAEEYAELGFRCQVHG
APDIDIESLVDRRAMRFHGRGTAWNHIAMDQAIADAGLTEEEVSNERTGI
IMGSGGPSTRTIVDSADITREKGPKRVGPFAVPKAMSSTASATLATFFKI
KGINYSISSACATSNHCIGNAYEMIQYGKQDRMFAGGCEDLDWTLSVLFD
AMGAMSSKYNDTPSTASRAYDKNRDGFVIAGGAGVLVLEDLETALARGAK
IYGEIVGYGATSDGYDMVAPSGEGAIRCMKMALSTVTSKIDYINPHATST
PAGDAPEIEAIRQIFGAGDVCPPIAATKSLTGHSLGATGVQEAIYSLLMM
QNNFICESAHIEELDPAFADMPIVRKRIDNVQLNTVLSNSFGFGGTNATL
VFQRYQG

3D structure

• PDB: 3mqd Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.
• Chain: A
• Resolution: 1.25 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C161 H296 E307 K328 H333 F391 F393
• Catalytic site (residue number reindexed from 1): C161 H296 E307 K328 H333 F391 F393
• Enzyme Commision number: 2.3.1.41: beta-ketoacyl-[acyl-carrier-protein] synthase I.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	3MQ	A	G105 G106 A160 C161 L195 F199 L335	G105 G106 A160 C161 L195 F199 L335

Gene Ontology

Molecular Function

• GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
• GO:0016746 acyltransferase activity
• GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

Biological Process

• GO:0006633 fatty acid biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:3mqd, PDBe:3mqd, PDBj:3mqd
• PDBsum: 3mqd
• PubMed: 31237717
• UniProt: Q2YQQ9