Structure of PDB 3mq4 Chain A

Receptor sequence
>3mq4A (length=386) Species: 9606 (Homo sapiens) [Search protein sequence]
HSIRIEGDVTLGGLFPVHAKGCGDIKRENGIHRLEAMLYALDQINSDPNL
LPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTKPEKVVGVIGASGS
SVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAM
VDIVKALGWNYVSTLGSYGEKGVESFTQISGGLSIAQSVRIPQEDFDRII
KQLLDTAVVIFANDEDIKQILHFLWVGSEGAITIQPKRATVEGFDAYFTS
RTLENNRRNVWFAEYWEENFNCKLKCTGQERIGKDSNYEQEGKVQFVIDA
VYAMAHALHHMNKDLCAVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFN
KNGDAPGRYDIFQYQNPGYRLIGQWTDELQLNIEDM
3D structure
PDB3mq4 mGluR7 complexed with LY341495
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A I89 D92 I44 D47
BS02 Z99 A R78 G158 S159 A180 S181 T182 Y230 K407 R33 G99 S100 A121 S122 T123 Y168 K293 BindingDB: IC50=990nM,Ki=990nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3mq4, PDBe:3mq4, PDBj:3mq4
PDBsum3mq4
PubMed
UniProtQ14831|GRM7_HUMAN Metabotropic glutamate receptor 7 (Gene Name=GRM7)

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