Structure of PDB 3mpm Chain A

Receptor sequence
>3mpmA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
WEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLA
EANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLT
INKLLDMAAQIAEGMAFIEERNYIHRNLRAANILVSDTLSCKIADFGLAR
LIEDNEYTARFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPY
PGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLR
SVLEDFF
3D structure
PDB3mpm New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N364 R366 A368 N369 D382 F402
Catalytic site (residue number reindexed from 1) N127 R129 A131 N132 D145 F161
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5LK A L251 A271 K273 E288 T316 Y318 M319 E320 G322 L371 L14 A34 K36 E51 T79 Y81 M82 E83 G85 L134 MOAD: ic50=30nM
PDBbind-CN: -logKd/Ki=7.52,IC50=30nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3mpm, PDBe:3mpm, PDBj:3mpm
PDBsum3mpm
PubMed20483608
UniProtP06239|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)

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