Structure of PDB 3mnp Chain A

Receptor sequence

>3mnpA (length=257) Species: 10090 (Mus musculus) [Search protein sequence]

MVPAALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGR
QVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMVFALGWRSYRQASGN
LLCFAPDLIINEQRMTLPCMYDQCKHMLFISTELQRLQVSYEEYLCMKTL
LLLSSVPKEGLKSQELFDEIRMTYIKELGKAIAKRGGNSSQNWQRFYQLT
KLLDSMHDVVENLLSYCFQTFLDKSMSIEFPEMLAEIITNQIPKYSNGNI
KKLLFHQ

3D structure

PDB

3mnp Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening.

Chain

Resolution

1.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	K585 M599 Q603 E761 N765	K60 M74 Q78 E236 N240
BS02	DEX	A	M566 L569 N570 G573 Q576 M607 M610 V611 F629 Q648 M652 Y741 C742 T745	M41 L44 N45 G48 Q51 M82 M85 V86 F104 Q123 M127 Y216 C217 T220

External links

PDB	RCSB:3mnp, PDBe:3mnp, PDBj:3mnp
PDBsum	3mnp
PubMed	20850457
UniProt	P06537\|GCR_MOUSE Glucocorticoid receptor (Gene Name=Nr3c1)

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