Structure of PDB 3mn8 Chain A

Receptor sequence
>3mn8A (length=383) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
KEDESFLQQPHYASQEQLEDLFAGLEKAYPNQAKVHFLGRSLEGRNLLAL
QISRNTRSRNLLTPPVKYIANMHGDETVGRQLLVYMAQYLLGNHERISDL
GQLVNSTDIYLVPTMNPDGYALSQEGNCESLPNYVGRGNAANIDLNRDFP
DRLEAQSRQPETAALVNWIVSKPFVLSANFHGGAVVASYPYDNSLAHNEC
CEESLTPDDRVFKQLAHTYSDNHPIMRKGNNCNDSFSGGITNGAHWYELS
GGMQDFNYAFSNCFELTIELSCCKYPAASTLPQEWQRNKASLLQLLRQAH
IGIKGLVTDASGFPIADANVYVAGLEEKPMRTSKRGEYWRLLTPGLYSVH
ASAFGYQTSAPQQVRVTNDNQEALRLDFKLAPV
3D structure
PDB3mn8 Structure-Function Analysis of the Short Splicing Variant Carboxypeptidase Encoded by Drosophila melanogaster silver.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.17.22: metallocarboxypeptidase D.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H101 E104 H217 H73 E76 H181
BS02 GEM A H101 E104 R165 N174 R175 H217 D228 G279 W282 Y283 L285 E305 H73 E76 R137 N146 R147 H181 D192 G243 W246 Y247 L249 E269 PDBbind-CN: -logKd/Ki=6.17,Ki=0.67uM
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3mn8, PDBe:3mn8, PDBj:3mn8
PDBsum3mn8
PubMed20600119
UniProtP42787|CBPD_DROME Carboxypeptidase D (Gene Name=svr)

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