Structure of PDB 3mlp Chain A

Receptor sequence

>3mlpA (length=337) Species: 10090 (Mus musculus) [Search protein sequence]

VLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIE
RTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMT
KQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDR
FFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVH
NNSKHGRRARRLDPSEAATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQ
VIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRF
IYTEPTIDYGFQRLQKVPKEVILKRAADLVEALYGMP

3D structure

PDB

3mlp Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R63 N66 F67 H157 C161 S162 R163 N172 G203 N204 R206 S238 K239 R242	R28 N31 F32 H122 C126 S127 R128 N137 G168 N169 R171 S203 K204 R207
BS02	dna	A	S169 G171 N174 N197 L199 N201 A202 G203 P205 F233 H235 N236 N237 H240	S134 G136 N139 N162 L164 N166 A167 G168 P170 F198 H200 N201 N202 H205
BS03	ZN	A	H157 C161 C164 C170	H122 C126 C129 C135

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:3mlp, PDBe:3mlp, PDBj:3mlp
PDBsum	3mlp
PubMed	20876732
UniProt	Q07802\|COE1_MOUSE Transcription factor COE1 (Gene Name=Ebf1)

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