Structure of PDB 3mkd Chain A

Receptor sequence
>3mkdA (length=692) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
NPIHDRTSDYHKYLKVKQGDSDLFKLTVSDKRYIWYNPDPKERDSYECGE
IVSETSDSFTFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPA
VFHNLRVRYNQDLIYTYSGLFLVAVNPFKRIPIYTQEMVDIFKGRRRNEV
APHIFAISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAG
RNQANGSGVLEQQILQANPILEAFGNAKTTRNNNSSRFGKFIEIQFNSAG
FISGASIQSYLLEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGP
ESFNYLNQSGCVDIKGVSDSEEFKITRQAMDIVGFSQEEQMSIFKIIAGI
LHLGNIKFEKGAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAG
RDLVAQHLNVEKSSSSRDALVKALYGRLFLWLVKKINNVLCQERKAYFIG
VLDIYGFEIFKVNSFEQLCINYTNEKLQQFFNHHMFKLEQEEYLKEKINW
TFIDFGLDSQATIDLIDGRQPPGILALLDEQSVFPNATDNTLITKLHSHF
SKKNAKYEEPRFSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFK
DSSDNVVTKLFNDPNIASRAKKGANFITVAAQYKEQLASLMATLETTNPH
FVRCIIPNNKQLPAKLEDKVVLDQLRCNGVLEGIRITRKGFP
3D structure
PDB3mkd Switch-2 dependent modulation of the myosin power stroke
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S181 G182 T186 N233 S236 S237 G457 E459
Catalytic site (residue number reindexed from 1) S180 G181 T185 N232 S235 S236 G456 E458
Enzyme Commision number 3.6.4.1: Transferred entry: 5.6.1.8.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T186 S237 T185 S236
BS02 ADP A N127 P128 K130 G182 G184 K185 T186 E187 N233 N126 P127 K129 G181 G183 K184 T185 E186 N232
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:3mkd, PDBe:3mkd, PDBj:3mkd
PDBsum3mkd
PubMed
UniProtP08799|MYS2_DICDI Myosin-2 heavy chain (Gene Name=mhcA)

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