Structure of PDB 3mk8 Chain A

Receptor sequence
>3mk8A (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
DELYRQSLEIISRYLREQATGASGATSRKALETLRRVGDGVQRNHETAFQ
GMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLK
TINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
3D structure
PDB3mk8 The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer.
ChainA
Resolution2.321 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H224 M231 H252 V253 S255 D256 G262 R263 T266 F318 F319 H45 M52 H73 V74 S76 D77 G83 R84 T87 F139 F140
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:3mk8, PDBe:3mk8, PDBj:3mk8
PDBsum3mk8
PubMed20562877
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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