Structure of PDB 3mk7 Chain A

Receptor sequence

>3mk7A (length=466) Species: 316 (Stutzerimonas stutzeri) [Search protein sequence]

TSTAYSYKVVRQFAIMTVVWGIVGMGLGVFIAAQLAWPFLNFDLPWTSFG
RLRPLHTNAVIFAFGGCALFATSYYSVQRTCQTTLFAPKLAAFTFWGWQL
VILLAAISLPLGFTSSKEYAELEWPIDILITIVWVAYAVVFFGTLAKRKV
KHIYVGNWFFGAFILTVAILHVVNNLEIPVTAMKSYSLYAGATDAMVQWW
YGHNAVGFFLTAGFLGIMYYFVPKQAERPVYSYRLSIVHFWALITVYIWA
GPHHLHYTALPDWAQSLGMVMSLILLAPSWGGMINGMMTLSGAWHKLRSD
PILRFLVVSLAFYGMSTFEGPMMAIKTVNALSHYTDWTIGHVHAGALGWV
AMVSIGALYHLVPKVFGREQMHSIGLINTHFWLATIGTVLYIASMWVNGI
AQGLMWRAINDDGTLTYSFVESLEASHPGFVVRMIGGAIFFAGMLVMAYN
TWRTVQAAKPAEYDAA

3D structure

PDB

3mk7 The Structure of cbb3 Cytochrome Oxidase Provides Insights into Proton Pumping

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEM	A	E122 Y123 W203 V210 L214 Y251 H257 H258 T321 G324 P325 M327 A328 H337 H345 V346 G349	E118 Y119 W199 V206 L210 Y247 H253 H254 T317 G320 P321 M323 A324 H333 H341 V342 G345
BS02	HEM	A	M29 G32 V33 I35 A36 R57 H60 V64 Y123 I343 V346 H347 A350 L351 Y395 G441	M25 G28 V29 I31 A32 R53 H56 V60 Y119 I339 V342 H343 A346 L347 Y391 G437
BS03	CU	A	H207 H257 H258	H203 H253 H254
BS04	CA	A	A124 L126 D131 N179	A120 L122 D127 N175

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0005506	iron ion binding
GO:0005507	copper ion binding
GO:0008121	ubiquinol-cytochrome-c reductase activity
GO:0015078	proton transmembrane transporter activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0006119	oxidative phosphorylation
GO:0009060	aerobic respiration
GO:0015990	electron transport coupled proton transport
GO:0019411	aerobic respiration, using ferrous ions as electron donor
GO:0019646	aerobic electron transport chain
GO:0022904	respiratory electron transport chain
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070069	cytochrome complex
GO:0098803	respiratory chain complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:3mk7, PDBe:3mk7, PDBj:3mk7
PDBsum	3mk7
PubMed	20576851
UniProt	D9IA43\|CCON1_STUST Cbb3-type cytochrome c oxidase subunit CcoN1 (Gene Name=ccoN1)

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