Structure of PDB 3mjh Chain A

Receptor sequence
>3mjhA (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
NKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLD
DTTVKFEIWDTAGLERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWV
KELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAK
TSMNVNEIFMAIAKKLPK
3D structure
PDB3mjh Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1).
ChainA
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A S29 A30 G32 K33 S34 S35 F45 H46 E47 Q49 S51 T52 G78 N133 K134 D136 S163 K165 S14 A15 G17 K18 S19 S20 F30 H31 E32 Q34 S36 T37 G63 N118 K119 D121 S148 K150
BS02 MG A S34 T52 S19 T37
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:3mjh, PDBe:3mjh, PDBj:3mjh
PDBsum3mjh
PubMed20534488
UniProtP20339|RAB5A_HUMAN Ras-related protein Rab-5A (Gene Name=RAB5A)

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