Structure of PDB 3mj1 Chain A

Receptor sequence
>3mj1A (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
GSVIDPSELTFVQEIGSGGLVHLGYWLNKDKVAIKTIEEAEVMMKLSHPK
LVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVC
EGMAYLEEASVIHRDLAARNCLVGENQVIKVSDFPVKWASPEVFSFSRYS
SKSDVWSFGVLMWEVFSEGKIPYERSNSEVVEDISTGFRLYKPRLASTHV
YQIMNHCWKERPEDRPAFSRLLRQLAAI
3D structure
PDB3mj1 Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation.
ChainA
Resolution1.72 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D482 A484 R486 N487 D500 P521
Catalytic site (residue number reindexed from 1) D115 A117 R119 N120 D133 P135
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 614 A I369 S371 A389 E436 F437 M438 E439 H440 G441 C442 L489 I15 S17 A33 E69 F70 M71 E72 H73 G74 C75 L122 MOAD: Kd=15nM
PDBbind-CN: -logKd/Ki=7.82,Kd=15nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3mj1, PDBe:3mj1, PDBj:3mj1
PDBsum3mj1
PubMed20545945
UniProtQ08881|ITK_HUMAN Tyrosine-protein kinase ITK/TSK (Gene Name=ITK)

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