Structure of PDB 3mgh Chain A

Receptor sequence
>3mghA (length=319) Species: 9606 (Homo sapiens) [Search protein sequence]
ATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQE
ACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKT
AQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQT
VQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLL
DSLRQEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIIVVPYSEFACAL
LYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNCKVGPGRVLPTPTE
KDVFRLLGLPYREPAERDW
3D structure
PDB3mgh Loop 1 modulates the fidelity of DNA polymerase lambda
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D179 D181 D237
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A W274 Q372 V462 G464 Y505 R517 K521 W26 Q124 V214 G216 Y252 R264 K268
BS02 dna A W342 G343 A344 G345 K347 T348 K472 Y505 W94 G95 A96 G97 K99 T100 K219 Y252
BS03 dna A Y267 W274 R275 G278 Y279 G304 G306 R308 M309 K312 Y19 W26 R27 G30 Y31 G56 G58 R60 M61 K64
BS04 dna A P547 R549 P291 R293
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3mgh, PDBe:3mgh, PDBj:3mgh
PDBsum3mgh
PubMed20435673
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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