Structure of PDB 3mfu Chain A

Receptor sequence
>3mfuA (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
DVLFEDVYELCEVIGKGAFSVVRRCINRETGQQFAVKIVDVAKFTSSPGL
STEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIV
KRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPENVLLASKEN
SAPVKLGDFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWG
CGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVR
RMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKL
KG
3D structure
PDB3mfu Evolution of CASK into a Mg2+-sensitive kinase.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D141 K143 E145 N146 D162 T182
Catalytic site (residue number reindexed from 1) D137 K139 E141 N142 D158 T178
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A V26 A39 K41 M94 L148 D162 V22 A35 K37 M90 L144 D158
BS02 MN A N146 D162 N142 D158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3mfu, PDBe:3mfu, PDBj:3mfu
PDBsum3mfu
PubMed20424264
UniProtO14936|CSKP_HUMAN Peripheral plasma membrane protein CASK (Gene Name=CASK)

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