Structure of PDB 3mfk Chain A

Receptor sequence
>3mfkA (length=138) Species: 9606 (Homo sapiens) [Search protein sequence]
GTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQ
SFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNI
IHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKPDA
3D structure
PDB3mfk Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y386 R391 R394 Y397 K404 R409 Y410 Y85 R90 R93 Y96 K103 R108 Y109
BS02 dna A Q336 L337 W375 K379 K381 M384 K388 R391 Y396 K399 Q35 L36 W74 K78 K80 M83 K87 R90 Y95 K98
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:3mfk, PDBe:3mfk, PDBj:3mfk
PDBsum3mfk
PubMed20686355
UniProtP14921|ETS1_HUMAN Protein C-ets-1 (Gene Name=ETS1)

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