Structure of PDB 3mel Chain A

Receptor sequence
>3melA (length=213) Species: 1351 (Enterococcus faecalis) [Search protein sequence]
SRVLLVAGGNPSDWPTIEPATYDYFVGIDRGCLHLLEADLPLQLAVGDFD
SLSREEYHFVQETTETLIQAPAEKDDTDTQLALQEALQRFPQAEMTIIGA
TGGRIDHLLANLWLPFEPRFQGVLRQIRLCDRQNSIQYYAPGSYIVPKEP
DKEYLAYCCLTPVENLTLRRSKYLLTNQDVPYPTSYASNEFIEEAAAFSF
DAGMIAVIQSKDK
3D structure
PDB3mel Northeast Structural Genomics Consortium Target EfR150
ChainA
Resolution2.788 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.6.2: thiamine diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP A K75 D76 T78 D79 T80 H108 K74 D75 T77 D78 T79 H107
BS02 MG A D30 D49 D51 D29 D48 D50
BS03 MG A N166 S200 N165 S199
Gene Ontology
Molecular Function
GO:0004788 thiamine diphosphokinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030975 thiamine binding
GO:0046872 metal ion binding
Biological Process
GO:0006772 thiamine metabolic process
GO:0009229 thiamine diphosphate biosynthetic process
GO:0016310 phosphorylation
GO:0042723 thiamine-containing compound metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3mel, PDBe:3mel, PDBj:3mel
PDBsum3mel
PubMed
UniProtQ82ZE3

[Back to BioLiP]