Structure of PDB 3mdd Chain A

Receptor sequence
>3mddA (length=385) Species: 9823 (Sus scrofa) [Search protein sequence]
GFSFELTEQQKEFQATARKFAREEIIPVAAEYDRTGEYPVPLLKRAWELG
LMNTHIPESFGGLGLGIIDSCLITEELAYGCTGVQTAIEANTLGQVPLII
GGNYQQQKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYII
NGQKMWITNGGKANWYFLLARSDPDPKAPASKAFTGFIVEADTPGVQIGR
KEINMGQRCSDTRGIVFEDVRVPKENVLTGEGAGFKIAMGTFDKTRPPVA
AGAVGLAQRALDEATKYALERKTFGKLLAEHQGISFLLADMAMKVELARL
SYQRAAWEIDSGRRNTYYASIAKAYAADIANQLATDAVQVFGGNGFNTEY
PVEKLMRDAKIYQIYEGTAQIQRIIIAREHIGRYK
3D structure
PDB3mdd Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) V135 T136 T255 E376 R388
Catalytic site (residue number reindexed from 1) V125 T126 T245 E366 R378
Enzyme Commision number 1.3.8.7: medium-chain acyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A Y133 T136 G141 S142 W166 T168 I371 T378 Q380 Y123 T126 G131 S132 W156 T158 I361 T368 Q370
BS02 FAD A R281 T283 F284 H291 Q349 V350 G353 R271 T273 F274 H281 Q339 V340 G343
Gene Ontology
Molecular Function
GO:0003995 acyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0042802 identical protein binding
GO:0050660 flavin adenine dinucleotide binding
GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity
Biological Process
GO:0001889 liver development
GO:0005978 glycogen biosynthetic process
GO:0006082 organic acid metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0007507 heart development
GO:0009409 response to cold
GO:0009437 carnitine metabolic process
GO:0009791 post-embryonic development
GO:0019254 carnitine metabolic process, CoA-linked
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042594 response to starvation
GO:0045329 carnitine biosynthetic process
GO:0051791 medium-chain fatty acid metabolic process
GO:0051793 medium-chain fatty acid catabolic process
GO:0055007 cardiac muscle cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0030424 axon
GO:0031966 mitochondrial membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3mdd, PDBe:3mdd, PDBj:3mdd
PDBsum3mdd
PubMed8356049
UniProtP41367|ACADM_PIG Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADM)

[Back to BioLiP]