Structure of PDB 3mbi Chain A

Receptor sequence
>3mbiA (length=287) Species: 50339 (Thermoplasma volcanium) [Search protein sequence]
SGMKIIALRSSLKLAARIAEELKTEPVMPDERRFPDGELYLRYDEDLTGH
NIFIIGNTHSDAEVMEMILTLSAIQDYRTKSVNIIAPYYGYARQHQRYKN
GEPISSQILTEIYSSYSNSIATVDIHDEKTLSYSKVKFSDLHANDAIVRY
YKNVDVDYVVSPDDGGLARVADISAKLGKKHFFIEKKRIDDRTVEMKVPN
VDVNGKKLLIVDDIISTGGTIAKSSGLLREKGASKIYVSAVHGLFVNGSE
NKILQNADEIHVTDTVESKFSDISVYQEVCNYIRDID
3D structure
PDB3mbi The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.6.1: ribose-phosphate diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A R186 S214 T215 G216 T218 R188 S216 T217 G218 T220
BS02 MG A H93 H124 H95 H126
BS03 ADP A R91 Q92 Y96 H124 K184 R186 R93 Q94 Y98 H126 K186 R188
BS04 ADP A F32 D34 E36 F34 D36 E38
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004749 ribose phosphate diphosphokinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process
GO:0006164 purine nucleotide biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0002189 ribose phosphate diphosphokinase complex
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3mbi, PDBe:3mbi, PDBj:3mbi
PDBsum3mbi
PubMed21963988
UniProtQ97CA5|KPRS_THEVO Ribose-phosphate pyrophosphokinase (Gene Name=prs)

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