Structure of PDB 3mak Chain A

Receptor sequence
>3makA (length=208) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
VDFYYLPGSSPCRSVIMTAKAVGVELNKKLLNLQAGEHLKPEFLKINPQH
TIPTLVDNGFALWESRAIQVYLVEKYGKTDSLYPKCPKKRAVINQRLYFD
MGTLYQSFANYYYPQVFAKAPADPEAFKKIEAAFEFLNTFLEGQDYAAGD
SLTVADIALVATVSTFEVAKFEISKYANVNRWYENAKKVTPGWEENWAGC
LEFKKYFE
3D structure
PDB3mak Structural evidence for conformational changes of Delta class glutathione transferases after ligand binding
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S10
Catalytic site (residue number reindexed from 1) S9
Enzyme Commision number 2.5.1.18: glutathione transferase.
4.5.1.1: DDT-dehydrochlorinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A S10 P12 H39 H51 T52 I53 E65 S66 S9 P11 H38 H50 T51 I52 E64 S65
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0016740 transferase activity
GO:0016829 lyase activity
GO:0018833 DDT-dehydrochlorinase activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0009636 response to toxic substance
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:3mak, PDBe:3mak, PDBj:3mak
PDBsum3mak
PubMed22475449
UniProtP20432|GSTD1_DROME Glutathione S-transferase D1 (Gene Name=GstD1)

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