Structure of PDB 3m7i Chain A

Receptor sequence

>3m7iA (length=632) Species: 192222 (Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819)

MNIQILQEQANTLRFLSADMVQKANSGHPGAPLGLADILSVLSYHLKHNP
KNPTWLNRDRLVFSGGHASALLYSFLHLSGYDLSLEDLKNFRQLHSKTPG
HPEISTLGVEIATGPLGQGVANAVGFAMAAKKAQNLLGSDLIDHKIYCLC
GDGDLQEGISYEACSLAGLHKLDNFILIYDSNNISIEGDVGLAFNENVKM
RFEAQGFEVLSINGHDYEEINKALEQAKKSTKPCLIIAKTTIAKGAGELE
GSHKSHGAPLGEEVIKKAKEQAGFDPNISFHIPQASKIRFESAVELGDLE
EAKWKDKLEKSAKKELLERLLNPDFNKIAYPDFKGKDLATRDSNGEILNV
LAKNLEGFLGGSADLGPSNKTELHSMGDFVEGKNIHFGIREHAMAAINNA
FARYGIFLPFSATFFIFSEYLKPAARIAALMKIKHFFIFTHDSIGVGEDG
PTHQPIEQLSTFRAMPNFLTFRPADGVENVKAWQIALNADIPSAFVLSRQ
KLKALNEPVFGDVKNGAYLLKESKEAKFTLLASGSEVWLCLESANELEKQ
GFACNVVSMPCFELFEKQDKAYQERLLKGEVIGVEAAHSNELYKFCHKVY
GIESFGESGKDKDVFERFGFSVSKLVNFILSK

3D structure

• PDB: 3m7i Crystal structure of transketolase in complex with thiamine diphosphate, ribose-5-phosphate(pyranose form) and magnesium ion
• Chain: A
• Resolution: 1.75 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H28 I242 H256 E391 H453
• Catalytic site (residue number reindexed from 1): H28 I242 H256 E391 H453
• Enzyme Commision number: 2.2.1.1: transketolase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TPP	A	H67 L116 D152 G153 N182 I184 I186 H256	H67 L116 D152 G153 N182 I184 I186 H256
BS02	MG	A	D152 N182 I184	D152 N182 I184
BS03	RP5	A	H28 H256	H28 H256

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004802 transketolase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006098 pentose-phosphate shunt

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:3m7i, PDBe:3m7i, PDBj:3m7i
• PDBsum: 3m7i
• UniProt: Q0P7Y3