Structure of PDB 3m6g Chain A

Receptor sequence

>3m6gA (length=353) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

TALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPSYVGDEAQSKRGILTLK
YPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREK
MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEG
YALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCY
VALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIG
MESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEIT
ALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPS
IVH

3D structure

PDB

3m6g Two molecules of lobophorolide cooperate to stabilize an actin dimer using both their "ring" and "tail" region.

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ATP	A	G13 S14 G15 K18 G156 D157 V159 G182 K213 E214 G301 G302 M305 Y306 K336	G8 S9 G10 K13 G138 D139 V141 G164 K195 E196 G283 G284 M287 Y288 K318
BS02	LO3	A	Y143 A144 S145 G146 R147 L346 L349 M355	Y125 A126 S127 G128 R129 L328 L331 M337
BS03	LO3	A	D24 D25 S344 I345	D19 D20 S326 I327

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003785	actin monomer binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005523	tropomyosin binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0019904	protein domain specific binding
GO:0031013	troponin I binding
GO:0031432	titin binding
GO:0032036	myosin heavy chain binding
GO:0042802	identical protein binding
GO:0048306	calcium-dependent protein binding
GO:0140660	cytoskeletal motor activator activity

	Biological Process
GO:0010628	positive regulation of gene expression
GO:0030041	actin filament polymerization
GO:0030240	skeletal muscle thin filament assembly
GO:0048741	skeletal muscle fiber development
GO:0051017	actin filament bundle assembly
GO:0090131	mesenchyme migration

	Cellular Component
GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005865	striated muscle thin filament
GO:0005884	actin filament
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0031941	filamentous actin
GO:0032432	actin filament bundle
GO:0044297	cell body
GO:0098723	skeletal muscle myofibril

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3m6g, PDBe:3m6g, PDBj:3m6g
PDBsum	3m6g
PubMed	20797609
UniProt	P68135\|ACTS_RABIT Actin, alpha skeletal muscle (Gene Name=ACTA1)

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