Structure of PDB 3m42 Chain A

Receptor sequence
>3m42A (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ
DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGEL
FSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTS
KRPNAILKLTDFGFAKETTGEKYDKSCDMWSLGVIMYILLCGYPPFYSPG
MKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW
IMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMR
3D structure
PDB3m42 Novel pyrrolo[2,3-f]isoquinoline based MAPKAP-K2 (MK2) inhibitors with potent in vitro and in vivo activity
ChainA
Resolution2.68 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 N191 D207
Catalytic site (residue number reindexed from 1) D140 K142 N145 D161
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S112 Q113 C114 I117 S66 Q67 C68 I71
BS02 HGF A L70 V78 K93 M138 L141 G144 L193 D207 L24 V32 K47 M92 L95 G98 L147 D161 BindingDB: IC50=700nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3m42, PDBe:3m42, PDBj:3m42
PDBsum3m42
PubMed
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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