Structure of PDB 3lz9 Chain A

Receptor sequence
>3lz9A (length=527) Species: 4097 (Nicotiana tabacum) [Search protein sequence]
RPVADFSPSLWGDQFLSFSIKNQVAEKYAKEIEALKEQTRNMLLATGMKL
ADTLNLIDTIERLGISYHFEKEIDDILDQIYNQNSNCNDLCTSALQFRLL
RQHGFNISPEIFSKFQDENGKFKESLASDVLGLLNLYEASHVRTHADDIL
EDALAFSTIHLESAAPHLKSPLREQVTHALEQCLHKGVPRVETRFFISSI
YDKEQSKNNVLLRFAKLDFNLLQMLHKQELAQVSRWWKDLDFVTTLPYAR
DRVVECYFWTLGVYFEPQYSQARVMLVKTISMISIVDDTFDAYGTVKELE
AYTDAIQRWDINEIDRLPDYMKISYKAILDLYKDYEKELSSAGRSHIVCH
AIERMKEIVRNYNVESTWFIEGYTPPVSEYLSNALATTTYYLLATTSYLG
MKSATEQDFEWLSKNPKILEASVIICRVIDDTATYEVEKSRGQIATGIEC
CMRDYGISTKEAMAKFQNMAETAWKDINEGLLRPTPVSTEFLTPILNLAR
IIEVTYIHNEKVLKPHIINLLVDSIKI
3D structure
PDB3lz9 Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates.
ChainA
Resolution2.28 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R264 W273 I294 D301 D305 T401 T402 T403 R441 D444 T448 E452 Y520
Catalytic site (residue number reindexed from 1) R250 W259 I280 D287 D291 T387 T388 T389 R427 D430 T434 E438 Y506
Enzyme Commision number 4.2.3.61: 5-epiaristolochene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FPF A R264 W273 D301 D305 T402 T403 R250 W259 D287 D291 T388 T389
BS02 MG A D301 D305 E379 D287 D291 E365
BS03 MG A D301 D305 D287 D291
BS04 MG A D444 T448 E452 D430 T434 E438
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0010333 terpene synthase activity
GO:0016829 lyase activity
GO:0016838 carbon-oxygen lyase activity, acting on phosphates
GO:0046872 metal ion binding
GO:0102698 5-epi-aristolochene synthase activity
Biological Process
GO:0006720 isoprenoid metabolic process
GO:0016102 diterpenoid biosynthetic process
GO:0016114 terpenoid biosynthetic process
GO:0051762 sesquiterpene biosynthetic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3lz9, PDBe:3lz9, PDBj:3lz9
PDBsum3lz9
PubMed20175559
UniProtQ40577|5EAS_TOBAC 5-epi-aristolochene synthase (Gene Name=EAS3)

[Back to BioLiP]