Structure of PDB 3lxp Chain A

Receptor sequence
>3lxpA (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNTGEMVAVKALKADAGPQ
HRSGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDY
LPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKI
GDFGLAKAVPEGHEYYRVGDSPVFWYAPECLKEYKFYYASDVWSFGVTLY
ELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPA
EVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQG
3D structure
PDB3lxp Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1023 A1025 R1027 N1028 D1041 P1064
Catalytic site (residue number reindexed from 1) D134 A136 R138 N139 D152 P172
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IZA A L903 G906 A928 I960 M978 E979 Y980 V981 G984 L1030 L16 G19 A39 I71 M89 E90 Y91 V92 G95 L141 BindingDB: IC50=1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3lxp, PDBe:3lxp, PDBj:3lxp
PDBsum3lxp
PubMed20478313
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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