Structure of PDB 3lxk Chain A

Receptor sequence
>3lxkA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
TIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ
QRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFL
QRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVK
IADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFG
VVLYELFTYCDKSCSPSAEFLRMMVPALSRLLELLEEGQRLPAPPACPAE
VHELMKLCWAPSPQDRPSFSALGPQLDML
3D structure
PDB3lxk Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D949 A951 R953 N954 D967
Catalytic site (residue number reindexed from 1) D135 A137 R139 N140 D153
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MI1 A G829 K830 G831 G834 S835 V836 A853 Y904 L905 R953 L956 D967 G15 K16 G17 G20 S21 V22 A39 Y90 L91 R139 L142 D153 MOAD: Ki=0.2nM
PDBbind-CN: -logKd/Ki=9.80,Kd=0.16nM
BindingDB: IC50=55nM,Ki=0.400000nM,Kd=2.2nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3lxk, PDBe:3lxk, PDBj:3lxk
PDBsum3lxk
PubMed20478313
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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