Structure of PDB 3lw0 Chain A

Receptor sequence
>3lw0A (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAI
KTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELM
TRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNC
MVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSD
VWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFEL
MRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK
3D structure
PDB3lw0 Allosteric IGF-1R Inhibitors.
ChainA
Resolution1.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1135 R1139 N1140 D1153 E1162
Catalytic site (residue number reindexed from 1) D144 R148 N149 D162 E171
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CCX A M1054 V1063 M1079 H1133 L1174 M72 V81 M97 H142 L180 PDBbind-CN: -logKd/Ki=6.40,IC50=0.4uM
BS02 CCX A Y1090 K1111 Q1114 M1115 E1118 F1147 E1271 P1272 Y108 K120 Q123 M124 E127 F156 E277 P278 PDBbind-CN: -logKd/Ki=6.40,IC50=0.4uM
BS03 CCX A G1273 V1277 G279 V283 PDBbind-CN: -logKd/Ki=6.40,IC50=0.4uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3lw0, PDBe:3lw0, PDBj:3lw0
PDBsum3lw0
PubMed24900194
UniProtP08069|IGF1R_HUMAN Insulin-like growth factor 1 receptor (Gene Name=IGF1R)

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