Structure of PDB 3luh Chain A

Receptor sequence

>3luhA (length=133) Species: 9606 (Homo sapiens)

KQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQP
CFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTV
LGMATQCVQMKNVQRTTPQTLSNLCLKINVKLG

3D structure

• PDB: 3luh Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
• Chain: A
• Resolution: 1.999 Å

Enzymatic activity

• Enzyme Commision number: 3.1.26.n2: argonaute-2.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	5GP	A	Y529 K533 Q545 C546 K570	Y90 K94 Q106 C107 K131	MOAD: Kd=3.3mM

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding

External links

• PDB: RCSB:3luh, PDBe:3luh, PDBj:3luh
• PDBsum: 3luh
• PubMed: 20505670
• UniProt: Q9UKV8|AGO2_HUMAN Protein argonaute-2 (Gene Name=AGO2)