Structure of PDB 3lug Chain A

Receptor sequence
>3lugA (length=133) Species: 9606 (Homo sapiens) [Search protein sequence]
KQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQP
CFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTV
LGMATQCVQMKNVQRTTPQTLSNLCLKINVKLG
3D structure
PDB3lug Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
ChainA
Resolution1.849 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.n2: argonaute-2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A K493 H507 Y512 K54 H68 Y73
BS02 C5P A Y529 K533 Q545 C546 K570 Y90 K94 Q106 C107 K131 MOAD: Kd=3.6mM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:3lug, PDBe:3lug, PDBj:3lug
PDBsum3lug
PubMed20505670
UniProtQ9UKV8|AGO2_HUMAN Protein argonaute-2 (Gene Name=AGO2)

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