Structure of PDB 3lud Chain A

Receptor sequence

>3ludA (length=133) Species: 9606 (Homo sapiens)

KQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQP
CFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTV
LGMATQCVQMKNVQRTTPQTLSNLCLKINVKLG

3D structure

• PDB: 3lud Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
• Chain: A
• Resolution: 2.095 Å

Enzymatic activity

• Enzyme Commision number: 3.1.26.n2: argonaute-2.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AMP	A	G524 K525 T526 Y529 K533 Q545 C546 Q548 K570	G85 K86 T87 Y90 K94 Q106 C107 Q109 K131	MOAD: Kd=0.26mM

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding

External links

• PDB: RCSB:3lud, PDBe:3lud, PDBj:3lud
• PDBsum: 3lud
• PubMed: 20505670
• UniProt: Q9UKV8|AGO2_HUMAN Protein argonaute-2 (Gene Name=AGO2)