Structure of PDB 3ls6 Chain A

Receptor sequence
>3ls6A (length=205) Species: 90371 (Salmonella enterica subsp. enterica serovar Typhimurium) [Search protein sequence]
SSFGTPFERVELALDALREGRGVMVLDDEDRENEGDMIFPAETMTVEQMA
LTIRHGSGIVCLCITEDRRKQLDLPMMVENNTSAYGTGFTVTIEAAEGVT
TGVSAADRVTTVRAAIKDGAKPSDLNRPGHVFPLRAQAGGVLTRGGHTEA
TIDLMTLAGFKPAGVLCELTNDDGTMARAPECIAFAGQHNMAVVTIEDLV
AYRQA
3D structure
PDB3ls6 Potential anti-bacterial drug target: structural characterization of 3,4-dihydroxy-2-butanone-4-phosphate synthase from Salmonella typhimurium LT2.
ChainA
Resolution1.86 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E38 D42 C67 Y91 F95 E100 H136 H153 E174
Catalytic site (residue number reindexed from 1) E32 D36 C61 Y85 F89 E94 H130 H147 E168
Enzyme Commision number 4.1.99.12: 3,4-dihydroxy-2-butanone-4-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A R37 R150 G152 H153 T154 R31 R144 G146 H147 T148
BS02 ZN A E38 H153 E32 H147
BS03 ZN A H61 H195 H55 H189
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity
GO:0016829 lyase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0009231 riboflavin biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:3ls6, PDBe:3ls6, PDBj:3ls6
PDBsum3ls6
PubMed20806221
UniProtP66032|RIBB_SALTY 3,4-dihydroxy-2-butanone 4-phosphate synthase (Gene Name=ribB)

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