Structure of PDB 3lpu Chain A

Receptor sequence
>3lpuA (length=144) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
DCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKL
AGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPSMNKELKKI
IGQVRDQAEHLKTAVQMAVFIHNKKRKGYSAGERIVDIIATDIQ
3D structure
PDB3lpu Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 976 A T125 A128 A129 T71 A74 A75 PDBbind-CN: -logKd/Ki=5.86,IC50=1.37uM
BS02 P03 A Q95 E96 Y99 Q41 E42 Y45
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:3lpu, PDBe:3lpu, PDBj:3lpu
PDBsum3lpu
PubMed20473303
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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