Structure of PDB 3lok Chain A

Receptor sequence
>3lokA (length=248) Species: 9031 (Gallus gallus) [Search protein sequence]
KDAWEIPRESLRLEVKLGFGEVWMGTWNGTTRVAIKTLEAQVMKKLRHEK
LVQLYAVVSEEPIYIVMEYMSKGCLLDFLKGEMGKYLRLPQLVDMAAQIA
SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLPIKWTAPEAAL
YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP
ECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
3D structure
PDB3lok Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance
ChainA
Resolution2.48 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404
Catalytic site (residue number reindexed from 1) D115 R117 A119 N120 D133
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DJK A A293 I294 M338 C345 A390 L393 D404 A34 I35 M67 C74 A119 L122 D133 PDBbind-CN: -logKd/Ki=6.92,IC50=120nM
BindingDB: IC50=>27000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3lok, PDBe:3lok, PDBj:3lok
PDBsum3lok
PubMed21080395
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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