Structure of PDB 3lmk Chain A

Receptor sequence
>3lmkA (length=438) Species: 9606 (Homo sapiens) [Search protein sequence]
RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLH
TLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDKPIVGVIGP
GSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQA
RAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGISIAHSYKIY
SNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEF
LLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETN
HRNPWFQEFWQHRFQCRLEGNKTCNSSLTLKTHHVQDSKMGFVINAIYSM
AYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFD
ENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD
3D structure
PDB3lmk Metabotropic Glutamate receptor mGluR5 complexed with glutamate
ChainA
Resolution2.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A Y64 W100 S151 S152 S173 A174 T175 Y223 D305 K396 Y40 W76 S102 S103 S124 A125 T126 Y174 D256 K339 PDBbind-CN: -logKd/Ki=5.94,Ki=1.16uM
BS02 MG A I79 N80 D82 L85 L86 I55 N56 D58 L61 L62
BS03 MG A F188 G460 D461 F139 G403 D404
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3lmk, PDBe:3lmk, PDBj:3lmk
PDBsum3lmk
PubMed
UniProtP41594|GRM5_HUMAN Metabotropic glutamate receptor 5 (Gene Name=GRM5)

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