Structure of PDB 3lm5 Chain A

Receptor sequence
>3lm5A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
ENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKR
RRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGE
IFSLCLPELEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSS
IYPLGDIKIVDFGMSRKIMGTPEYLAPEILNYDPITTATDMWNIGIIAYM
LLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKN
PEKRPTAEICLSHSWLQQWDFENL
3D structure
PDB3lm5 A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
ChainA
Resolution2.29 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D158 K160 Q162 N163 D179 T198
Catalytic site (residue number reindexed from 1) D140 K142 Q144 N145 D161 T171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QUE A A60 K62 E80 I94 L110 E111 Y112 L165 V178 D179 A43 K45 E63 I77 L93 E94 Y95 L147 V160 D161
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3lm5, PDBe:3lm5, PDBj:3lm5
PDBsum3lm5
PubMed33215924
UniProtO94768|ST17B_HUMAN Serine/threonine-protein kinase 17B (Gene Name=STK17B)

[Back to BioLiP]