Structure of PDB 3llf Chain A

Receptor sequence
>3llfA (length=217) Species: 187420 (Methanothermobacter thermautotrophicus str. Delta H) [Search protein sequence]
DVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDII
AEFRKRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFPGADSV
RACLNVAEEMGREVFLLTEMPHPGAEMFIQGAADEIARMGVDLGVKNYVG
PSTRPERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIY
LADNPAAAAAGIIESIK
3D structure
PDB3llf Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation.
ChainA
Resolution1.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K42 D70 K72 D75
Catalytic site (residue number reindexed from 1) K36 D64 K66 D69
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UP6 A D20 K42 D70 K72 L123 M126 P127 P180 Q185 G202 R203 D14 K36 D64 K66 L117 M120 P121 P174 Q179 G196 R197 BindingDB: Ki=12400nM
BS02 UP6 A D75 I76 T79 D69 I70 T73 BindingDB: Ki=12400nM
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:3llf, PDBe:3llf, PDBj:3llf
PDBsum3llf
PubMed20369850
UniProtO26232|PYRF_METTH Orotidine 5'-phosphate decarboxylase (Gene Name=pyrF)

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