Structure of PDB 3lkz Chain A

Receptor sequence
>3lkzA (length=262) Species: 11082 (West Nile virus) [Search protein sequence]
GRTLGEVWKERLNQMTKEEFTRYRKEAIIEVDRSAAKHARKEGNVTGGHP
VSRGTAKLRWLVERRFLEPVGKVIDLGCGRGGWCYYMATQKRVQEVRGYT
KGGPGHEEPQLVQSYGWNIVTMKSGVDVFYRPSECCDTLLCDIGESSSSA
EVEEHRTIRVLEMVEDWLHRGPREFCVKVLCPYMPKVIEKMELLQRRYGG
GLVRNPLSRNSTHEMYWVSRASGNVVHSVNMTSQVLLGRMEKRTWKGPQY
EEDVNLGSGTRA
3D structure
PDB3lkz Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG A S56 G58 G81 G86 W87 K105 H110 E111 D131 V132 F133 D146 I147 S52 G54 G77 G82 W83 K101 H106 E107 D127 V128 F129 D142 I143 PDBbind-CN: -logKd/Ki=6.15,IC50=0.7uM
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3lkz, PDBe:3lkz, PDBj:3lkz
PDBsum3lkz
PubMed20685660
UniProtQ9Q6P4|POLG_WNV9 Genome polyprotein (Gene Name=GP1)

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