Structure of PDB 3lka Chain A

Receptor sequence
>3lkaA (length=158) Species: 9606 (Homo sapiens) [Search protein sequence]
GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTG
MADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTT
HSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDI
RGIQSLYG
3D structure
PDB3lka Entropic contribution to the linking coefficient in fragment based drug design: a case study.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H218 E219 H222 H228
Catalytic site (residue number reindexed from 1) H113 E114 H117 H123
Enzyme Commision number 3.4.24.65: macrophage elastase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H218 H222 H228 H113 H117 H123
BS02 ZN A H168 D170 H183 H196 H63 D65 H78 H91
BS03 CA A D158 G190 I191 G192 D194 D53 G85 I86 G87 D89
BS04 CA A D124 E199 E201 D19 E94 E96
BS05 CA A D175 G176 G178 I180 D198 E201 D70 G71 G73 I75 D93 E96
BS06 M4S A T215 H218 E219 P238 Y240 T110 H113 E114 P133 Y135 MOAD: Kd=1.5mM
PDBbind-CN: -logKd/Ki=2.82,Kd=1.5mM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3lka, PDBe:3lka, PDBj:3lka
PDBsum3lka
PubMed20415416
UniProtP39900|MMP12_HUMAN Macrophage metalloelastase (Gene Name=MMP12)

[Back to BioLiP]