Structure of PDB 3lij Chain A

Receptor sequence

>3lijA (length=465) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence]

YFQGDLQATPGMFITSKKGHLSEMYQRVKKLGSGEVLLCRDKVTHVERAI
KIIRKSSNSKLLEEVAVLKLLDHPNIMKLYDFFEDKRNYYLVMECYKGGE
LFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESK
EKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVLRKKYDEKCDVWS
IGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLI
KQMLQFDSQRRISAQQALEHPWIKEMCSKKESLPSLANAIENMRKFQNSQ
KLAQAALLYMASKLTSQEETKELTDIFRHIDKNGDGQLDRQELIDGYSKL
SGEEVAVFPQIESEVDAILGAADFDRNGYIDYSEFVTVAMDRKSLLSKDK
LESAFQKFDQDGNGKISVDELASVFLDHLESKTWKEMISGIDSNNDGDVD
FEEFCKMIQKLCSNN

3D structure

PDB

3lij Crystal structure of full length CpCDPK3 (cgd5_820) in complex with Ca2+ and AMPPNP

Chain

Resolution

1.9 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D184 K186 E188 N189 D205 T224
Catalytic site (residue number reindexed from 1)	D139 K141 E143 N144 D160 T179
Enzyme Commision number	2.7.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	D379 N381 D383 Q385 E390	D331 N333 D335 Q337 E342
BS02	CA	A	D423 D425 N427 Y429 D431 E434	D373 D375 N377 Y379 D381 E384
BS03	CA	A	D459 D461 N463 K465 E470	D409 D411 N413 K415 E420
BS04	CA	A	D493 N495 D497 D499 E504	D442 N444 D446 D448 E453
BS05	MG	A	N189 D205	N144 D160
BS06	ANP	A	L68 G69 V76 K91 Y141 E145 L191	L31 G32 V36 K51 Y96 E100 L146

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calcium/calmodulin-dependent protein kinase activity
GO:0005509	calcium ion binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0009931	calcium-dependent protein serine/threonine kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006468	protein phosphorylation
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3lij, PDBe:3lij, PDBj:3lij
PDBsum	3lij
PubMed
UniProt	Q5CS01

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