Structure of PDB 3lgp Chain A

Receptor sequence
>3lgpA (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAW
DNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKML
LEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGHGGVCPKAYYSPV
GKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAEC
APNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQER
S
3D structure
PDB3lgp Structure and activity relationships of tartrate-based TACE inhibitors.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.86: ADAM 17 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H405 H409 H415 H182 H186 H192
BS02 50X A T347 G349 L350 E398 L401 H405 E406 H409 H415 V434 Y436 P437 I438 A439 V440 S441 N447 T130 G132 L133 E175 L178 H182 E183 H186 H192 V211 Y213 P214 I215 A216 V217 S218 N224 MOAD: Ki=2nM
PDBbind-CN: -logKd/Ki=8.70,Ki=2nM
BindingDB: Ki=2nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3lgp, PDBe:3lgp, PDBj:3lgp
PDBsum3lgp
PubMed20638281
UniProtP78536|ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (Gene Name=ADAM17)

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