Structure of PDB 3lgd Chain A

Receptor sequence
>3lgdA (length=482) Species: 9606 (Homo sapiens) [Search protein sequence]
SIDETRAHLLLKEKMMRLGGRLVLNTKEELANERLMTLKIAEMKEAMRTL
IFPPSMHFFQAKHLIERSQVFNILRMMPKGAALHLHDIGIVTMDWLVRNV
TYRPHCHICFTPRGIMQFRFAHPTPRPSEKCSKWILLEDYRKRVQNVTEF
DDSLLRNFTLVTQHPEVIYTNQNVVWSKFETIFFTISGLIHYAPVFRDYV
FRSMQEFYEDNVLYMEIRARLLPVYELSGEHHDEEWSVKTYQEVAQKFVE
THPEFIGIKIIYSDHRSKDVAVIAESIRMAMGLRIKFPTVVAGFDLVGHE
DTGHSLHDYKEALMIPAKDGVKLPYFFHAGETDWQGTSIDRNILDALMLN
TTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLVSDLRNHPVAT
LMATGHPMVISSDDPAMFGAKGLSYDFYEVFMGIGGMKADLRTLKQLAMN
SIKYSTLLESEKNTFMEIWKKRWDKFIADVAT
3D structure
PDB3lgd Structural basis for the growth factor activity of human adenosine deaminase ADA2.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.4: adenosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H86 H88 H330 D415 H84 H86 H328 D413
Gene Ontology
Molecular Function
GO:0004000 adenosine deaminase activity
GO:0019239 deaminase activity
Biological Process
GO:0006154 adenosine catabolic process
Cellular Component
GO:0005615 extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3lgd, PDBe:3lgd, PDBj:3lgd
PDBsum3lgd
PubMed20147294
UniProtQ9NZK5|ADA2_HUMAN Adenosine deaminase 2 (Gene Name=ADA2)

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